Complexes de serumalbumine humaine-porphyrine pouvant fixer l'oxygene et leurs utilisations therapeutiques

Human serum albumin-porphyrin complexes with the ability to bind oxygen and therapeutic uses thereof


The invention is directed to human serum albumin-porphyrin (HSA-P) complexes which are capable of reversible oxygen binding and their uses. These complexes may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or in applications requiring plasma expanders. Methods for the production of these complexes are provided. In a specific example, HSA-P complexes are shown to exhibit reversible oxygen binding. In another example, the HSA-P complex does not exhibit appreciable vasoactivity.
La présente invention concerne des complexes de sérumalbumine humaine-porphyrine (HSA-P) capables de fixer l'oxygène de manière réversible et leurs utilisations. Ces complexes peuvent s'utiliser dans des applications nécessitant des transporteurs physiologiques de l'oxygène comme dans les solutions de succédané du sang, ou dans des applications nécessitant des succédanées du plasma. L'invention concerne des procédés de production de ces complexes. Dans un exemple particulier, est mise en évidence la capacité des complexes HSA-P de fixer l'oxygène de manière réversible. Dans un autre exemple, le complexe HSA-P ne fait pas preuve d'une vasoactivité appréciable.




Download Full PDF Version (Non-Commercial Use)

Patent Citations (0)

    Publication numberPublication dateAssigneeTitle

NO-Patent Citations (6)

    ANALYTICA CHIMICA ACTA, Vol. 300, No. 1-3, issued January 1995, TIE et al., "Peroxidatic Activity of Metalloporphyrin Binding to Serum Albumin: Enhancement Effect of Serum Albumin on Metalloporphyrin Catalyzed Luminol Chemiluminescence Reaction", pages 215-220.
    BIOCHEM. J., Volume 270, issued March 1990, COHEN et al., "Binding of Porphyrin to Human Serum Albumin", pages 325-330.
    CHEMISTRY LETTERS, issued 1991, SAGAWA et al., "Stereoselective Dioxygenolysis of a Tryptophan Derivative Catalyzed by a Manganese Porphyrin Bound to Bovine Serum Albumin", pages 2083-2086.
    CRC CRIT. REV. THERAPEUTIC DRUG CARRIER SYSTEMS, Volume 3, No. 1, issued 1986, DELLACHERIE et al., "Synthetic Carriers of Oxygen", pages 41-94.
    J. AMER. CHEM. SOC., Volume 97, issued 1975, COLLMAN et al., "'Picket Fence Porphyrins', Synthetic Models for Oxygen Binding Hemoproteins", pages 1427-1439.
    See also references of EP 0775157A4

Cited By (11)

    Publication numberPublication dateAssigneeTitle
    EP-0739634-A2October 30, 1996The Green Cross CorporationPorphyrin metal complex-albumin inclusion compound and oxygen carrier composition comprising the same
    EP-0739634-A3March 31, 1999The Green Cross CorporationComposé d'inclusion d'un complexe de porphyrine-métaux et de l'albumine et porteur d'oxygène le contenant
    EP-1538151-A1June 08, 2005Nipro CorporationSupport d' oxygène artificiel et son procédé de fabrication
    EP-1714691-A1October 25, 2006Nipro CorporationMéthode pour ôter le monoxyde de carbone d'un transporteur d'oxygène telle l'hémoglobine
    EP-1880721-A1January 23, 2008Nipro CorporationAgent for improving circulatory disorder
    EP-1880721-A4May 27, 2009Nipro CorpAgent ameliorant les troubles circulatoires
    US-6008198-ADecember 28, 1999Yoshitomi Pharmaceutical Industries, Ltd.Porphyrin metal complex-albumin inclusion compound and oxygen carrier composition comprising the same
    US-7125862-B2October 24, 2006Japan Science And Technology AgencyPorphyrin-metal complexes and oxygen infusions containing the same
    US-7601201-B2October 13, 2009Nipro CorporationMethod of removing carbon monoxide from an oxygen carrier and apparatus for removing carbon monoxide
    WO-0200228-A1January 03, 2002Rohto Pharmaceutical Co., Ltd.Composition ophtalmique contenant de l'oxygene
    WO-03011866-A1February 13, 2003Japan Science And Technology CorporationPorphyrin-metal complexes and oxygen infusions containing the same