Uncharged antisense oligonucleotides targeted to bacterial 16s and 23s prnas and their uses

Procede et composition d'antisens antibacterien

Abstract

The invention relates to compositions comprising oligomers antisense to bacterial 16S or 23S rRNA and capable of selectively modulating the biological activity thereof, and methods for their use. More particularly, the invention relates to antisense oligomers directed to 16S or 23S rRNA found in one or more particular bacteria, or generally conserved among bacteria in general, and to pharmaceutical compositions and methods of treatment comprising the same.
La présente invention concerne des compositions comprenant des oligomères d'antisens aux bactéries d'ARNr 16S ou 23S et capables de moduler de manière sélective l'activité biologique de celles-ci, et leur procédés d'utilisation. Plus particulièrement, l'invention concerne des oligomères d'antisens dirigés contre les ARNr 16S ou 23S qui se trouvent dans une ou plusieurs bactéries spécifiques, ou qui se conservent parmi les bactéries en général, et des compositions pharmaceutiques les comprenant et des procédés de traitement les utilisant.

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