Methode de preparation d'un acarbose de grande purete

A process for preparing acarbose with high purity

Abstract

Disclosed herein is a process for preparing highly pure acarbose of formula (I) useful as medicine for the treatment of diabetes. The disclosed process comprises prepurifying an acarbose-containing solution using a synthetic adsorbent to produce a prepurified acarbose having an acarbose content of a predetermined level or more; and contacting the prepurified acarbose with a monodispersed, strongly acid cation exchanger, in one step, to absorb acarbose.
L'invention concerne une méthode de préparation d'un acarbose de grande pureté de la formule (I), qui s'utilise comme médicament pour le traitement du diabète. Ladite méthode de préparation consiste à effectuer une première purification d'une solution contenant l'acarbose, au moyen d'un adsorbent synthétique, afin de produire un acarbose préalablement purifié présentant une teneur en acarbose d'au moins un niveau préétabli. La méthode consiste ensuite à placer, en une étape, l'acarbose préalablement purifié au contact d'un échangeur de cations fortement acide monodispersé, pour absorber l'acarbose.

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Cited By (5)

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    CN-102030786-AApril 27, 2011丽珠集团新北江制药股份有限公司一种阿卡波糖的制备方法
    KR-20160032959-AMarch 25, 2016한국항공우주연구원Apparatus and method for monitoring remote
    US-6734300-B2May 11, 2004Va, Farmaceutska Industrija, DdAcarbose purification process
    WO-03014135-A1February 20, 2003Biogal Gyogyszergyar Rt, Teva Pharmaceuticals Usa, Inc.Method for purification of acarbose
    WO-03035659-A1May 01, 2003Pliva D.D.Acarbose purification process